Translational Research
Though term 'biology' is used but its major goal is to translate the biological knowledge towards clinical medicine. According to Dr. Arkin of Institute of Systems Biology, Seattle: "I see the biggest impact that systems biology is going to have is in fundamentally changing the success rate in clinical trials." In this connection the comment of Thomas Paterson, chief scientific officer at Entelos is pertinent: ‘‘The end point that we care about is not a protein–protein interaction. It is not even how a cell behaves in culture. It is how the integrated human system is going to behave’’. Though clinical medicine revolves around the central concept of “homeostasis”, but biased with reductionism, modern medicine ignores the complex interactions and dynamical aspects of homeostasis and gives more emphasis on singular factor. The notion of this approach is “divide and conquer”, where the complex problems have been tried to be solved by dividing them into smaller, simpler, and thus more tractable units. Conceptually, modern medicine is governed with evidence based medicine which relies on randomized clinical trials that ultimately lead towards statistical reasoning. As a result, medical care is only concerned to treat the individual patient with respect to the sample mean. Though it is easy to be implemented but lead to theoretical dogma, as in many cases it does not give a clue why a specific patient cannot respond to a therapeutic regime (Ahn et al, 2006, PloS Med, 3: 709-713; Pizzorno J, Intgr. Medicine, 2009, 8:8–11). The comment of Hiroki Kitano is also in the same direction “To understand biology at the system level, we must examine the structure and dynamics of cellular and organismal function, rather than the characteristics of isolated parts of a cell or organism. Properties of systems, such as robustness, emerge as central issues, and understanding these properties may have an impact on the future of medicine”.
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