Society for Systems Biology & Translational Research

An experiment is a study in which the researcher manipulates the level of some independent variable and then measures the outcome. Experiments are powerful techniques for evaluating cause-and-effect relationships. Many researchers consider experiments the "gold standard" against which all other research designs should be judged. Experiments are conducted both in the laboratory and in real life situations.

Further reading : Friday Jan 31, 2020 SSBTR Think Tank

To see the list of journals in the area of Systems Biology See our blog "Journals in Systems Biology" Saturday, 3rd Oct 2015

Systems Biology is an area that needs a multi-/interdisciplinary framework, and hence needs a different curriculum.

• Experts from Europe are now thinking on it. Please see our blog on Thursday, 26 May 2016 for details.
• Comments from Indian experts are also important, as India not only holds the central position in South Asian countries but also it holds the wide variations of cultural and ethnic diversity. For details please see our Research Section.

An early comprehensive review shows a logical merging of the separated disciplines - Life Sciences, Biotechnology, Bioengineering, Physiology and Medicine by Ideker T, Winslow R, Lauffenburger AD (2006) Bioengineering and Systems Biology, Annals of Biomedical Engineering, DOI: 10.1007/s10439-005-9047-7

The job opportunities aren't necessarily tied to a specific geographic location, either. Collaborators can work remotely on a common project. Wet-lab data generated at one site might be analyzed by group members cyber-networking from a distance. "It's more about getting the right people together to address the problem, no matter where they are," says Hlatky. Systems biologists just need "the ability to see the big picture and to have an open mind. Anyone can get into this game."

Career: Actually, all researchers need to get into the game, according to Jens Nielsen, professor of systems biology at Chalmers University of Technology, Göteborg, Sweden. "The tools, techniques, and approaches of systems biology are becoming standard in research and industry," he says. "To get a life science job in 10 or 20 years, you will simply be expected to have competency in it.”

A list of research groups engaged in Systems Biology research.

DiStefano III Joseph. (2014) Academic Press (Elsevier), London, San Diego.

Wolkenhauer O, Auffray C, Jaster R, Steinhoff G & Dammann O. (2013), Pediatric Research, 73:502-507.

Majumder D, Mukherjee A. (2013), Advances in Cancer: Research & Treatment, 2013, Article ID 587889, DOI: 10.5171/2013/587889.

Majumder D, Mukherjee A. (2011), Analyst, 136: 663-678, DOI: 10.1039/c0an00746c

Majumder D. (2009), Technorama 58: 7-20.

Can medicine meet with engineering ,ie, could medicine be explained or modified with the engineering principles?

Mayr E (2004). Cambridge University Press, Cambridge, New York, Melbourne, Madrid, Singapore.
"Apart from the insistence that biology is not reducible to chemistry and physics, ...the book covers many useful themes. Twelve chapters span topics such as evolutionary theory, ..., the origin of humans and astrobiology. The main strength of the book is that each topic is discussed clearly, and is often broken down into simpler ideas to allow components to be evaluated or tested separately. A particularly strong feature is Mayr’s destruction of orthogenesis, the ‘Onward and Upward’ model of evolution that still dominates much current thinking (especially from molecular biologists untrained in evolution). Orthogenesis implies an almost inevitable advance to a higher state: prokaryotes to eukaryotes, unicellular to multicellular organisms, primates to humans" by D Penny in Biology and 'physics envy' 2005 | EMBO Reports | 6 |

In this book [IM Makarov (Editor), (1987) MIR Publishers, Moscow] contributors discuss the achievements in biology from the viewpoint of cybernetics, describe multiple functions that constitute living matter, the basis of brain reliability, the psychics modeling limits, and the mathematical methods in psychology. Also they examine the problems relating to life and age, death and immortality, and the experimental ways of making life longer.

Brief Contents :
I. Biology & Information : a. Biology Today, b. Cybernetics standpoint
II. The Complexity of Living Systems : a. Integrity of Life, b. Brain and Intelligence
III. Difficulties on the Road to Truth : a. Scientific Methods in Cognition, b. New Horizon

With its focus on multi-disciplinary collaboration, translational research has the potential to advance applied science. This has been attempted particularly in medicine with translational medicine, research that aims to move “from bench to bedside” or from laboratory experiments through clinical trials to point-of-care patient applications.

Systems biology is the computational and mathematical modeling of complex biological systems. It is an emerging engineering approach applied to biomedical research. Systems Biology is a biology-based inter-disciplinary field of study that focuses on complex interactions within biological systems, using a holistic approach to biomedical research.

Cybernetics is a transdisciplinary approach for exploring regulatory systems, their structures, constraints, and possibilities. Cybernetics is relevant to the study of systems, such as mechanical, physical, biological, cognitive, and social systems. Cybernetics is applicable when a system being analyzed incorporates a closed signaling loop; that is, where action by the system generates some change in its environment and that change is reflected in that system in some manner (feedback) that triggers a system change...

A biological system is a complex network of biologically relevant entities. As biological organization spans several scales, examples of biological systems are populations of organisms, or on the organ- and tissue scale in mammals...